| 세션명 | Natural Polymers: Materials, Processing, and Applications |
|---|---|
| 발표장 | 제3회장 (201-202) |
| 논문코드 | 1L3-5 |
| 발표일 | 2018-10-11 |
| 발표시간 | 15:30-16:00 |
| 논문제목 | Smart Hyaluronic Acid Derivatives for Biomedical Applications |
| 발표자 | 한세광 |
| 발표자 소속 | 포항공과대학교 |
| 저자 | 한세광†, 황병우, 한슬기 |
| 소속 | 포항공과대학교 |
| 논문초록 | Hyaluronic acid (HA) is a naturally-occurring polysaccharide with excellent biocompatibility, viscoelasticity, biodegradability, and hygroscopic properties. Here, we developed poly(allylamine), PAAm modified upconversion nanoparticle / HA - rose bengal (UCNP/PAAm/HA-RB) conjugate complex for photochemical tissue bonding with near-infrared (NIR) light illumination. Compared to the conventional invasive treatment via suturing and stapling, UCNP/PAAm/HA-RB conjugate complex could be non-invasively delivered into the deep tissue and accelerate the tissue bonding upon NIR light illumination. In addition, we developed in situ supramolecularly assembled and modularly modified HA hydrogels for genetically engineered mesenchymal stem cell (eMSC) therapy. The long-term expression of mutant interleukin-12 by eMSCs within the supramolecular HA hydrogels resulted in effective inhibition of tumor growth with a significantly enhanced survival rate. |
THE POLYMER SOCIETY OF KOREA